Unsuccessful mitosis in multicellular tumour spheroids
نویسندگان
چکیده
منابع مشابه
Unsuccessful mitosis in multicellular tumour spheroids
Multicellular spheroids are very attractive models in oncology because they mimic the 3D organization of the tumour cells with their microenvironment. We show here using 3 different cell types (mammary TSA/pc, embryonic kidney Hek293 and cervical cancer HeLa), that when the cells are growing as spheroids the frequency of binucleated cells is augmented as occurs in some human tumours.We therefor...
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Multicellular tumour spheroids grown in vitro have been widely used in cancer research as an experimental preparation with many of the characteristics of tumours. They provide a model system for understanding the optical behaviour of tumour tissue, which is of interest in novel diagnostic and therapeutic procedures. Optical measurements on fresh spheroids in the wavelength range of 600-1000 nm ...
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A partial differential equation model is developed to understand the effect that nutrient and acidosis have on the distribution of proliferating and quiescent cells and dead cell material (necrotic and apoptotic) within a multicellular tumour spheroid. The rates of cell quiescence and necrosis depend upon the local nutrient and acid concentrations and quiescent cells are assumed to consume less...
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@ 0///)// ! 115 $8$68 8 145 "!36"$6768""6! ######63$"8 (BLOCKIN#AA+9+++AAAABC######63$"8* When you leave your homeland, you leave a part of your heart there. It needs many big hearts to repair it. I have been blessed to have so many warm hearted people around me to complete my lost piece of heart. To my beloved husband Pasha and my precious son Attila List of enclosed papers This thesis is base...
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Three-dimensional multicellular spheroids (MCSs) have a complex architectural structure, dynamic cell-cell/cell-matrix interactions and bio-mimicking in vivo microenvironment. As a fundamental building block for tissue reconstruction, MCSs have emerged as a powerful tool to narrow down the gap between the in vitro and in vivo model. In this review paper, we discussed the structure and biology o...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2017
ISSN: 1949-2553
DOI: 10.18632/oncotarget.15673